Copper Tripeptide-1 (GHK-Cu)

A naturally occurring complex of the tripeptide GHK with a copper ion — one of the most-studied peptides in skincare, first identified in human plasma.

How it works

GHK-Cu declines in skin with age. Research associates the topical peptide with signalling roles in tissue remodelling: markers of collagen and glycosaminoglycan production, and support for the skin’s repair processes. The copper it carries is also a cofactor for antioxidant enzymes.

Where it fits

Barrier-repair and recovery formulations, where its repair-signalling associations complement replacement lipids like ceramides.

Tolerability

Well tolerated; conventionally kept apart from strong direct acids in the same application, which can destabilise the copper complex.

Pregnancy and breastfeeding

No established concerns at topical cosmetic levels; conventionally considered suitable.