Cosmedix

Chirality is the organising idea. Many skincare ingredients exist in two mirror-image forms, and skin generally responds to one. Cosmedix formulates with that form only, which the brand credits for stronger results at lower irritation. The retinoids follow the same logic: encapsulated vitamin A in a ladder from Refine to Serum 16 to Define, released slowly so the skin adjusts.

Around the actives sits a plant-led base, neem, squalane, hyaluronic acid and gluconolactone, and a growing microbiome range, Harmonize and the Micro Defense sheet mask, for skin that reacts to conventional actives.

Refine is the gentlest retinol, Serum 16 the retinal step, Define the resurfacing retinoid with AHAs. Bakuchiol Complete is the no-retinoid alternative. Purity Clean and Benefit Clean are the cleansers, Humidify and Skin Thirst the moisturisers for dry and oily skin respectively, and Rescue the recovery mask.

Cosmedix formulas are fragrance-free as a rule but several contain essential oils, so patch test reactive skin. Define and Clarity are advisory tier; the rest of the range is open, and the retinoids are not for pregnancy.