Serum 16

Name: Serum 16
Brand: Cosmedix
SKU: CMX-S16-30
Price: 158.00 AUD
Availability: InStock

$158.00

A night-use serum built around LG-Retinex — Cosmedix's paired retinal and retinol complex — in a safflower oleosome base, positioned between entry retinol and prescription strength.

Key actives Retinaldehyde (Retinal)·Retinol·Hyaluronic Acid·Squalane

When to use Evening, 2–3 nights a week building as tolerated

How it works

Retinal, slowed down on purpose

Retinal sits one conversion step from retinoic acid, faster-acting than retinol, and usually punchier to adjust to. Serum 16 answers that with delivery: safflower oleosomes, natural oil-storage spheres from the seed, hold the retinal-retinol pair and release it gradually across the night rather than all at once.

What that buys

Research associates retinal with faster visible results than retinol at comparable tolerability, and time-release delivery is associated with narrowing that tolerability gap further. The practical outcome: a retinal serum that behaves gently.

The supporting hydration

Hyaluronic acid, glycosaminoglycans, polyglutamate and squalane build the moisture scaffolding retinoid skin wants, with proline riding along and honeysuckle extracts in support.

Non-negotiable

Evenings only; the adjustment period still exists, just softened. Daily broad-spectrum SPF every morning.

Who it suits

Skin that wants retinal’s pace without the drama, including graduates from retinol and careful first-timers guided by their clinician.

Not suitable

During pregnancy or while breastfeeding, in line with standard retinoid guidance.

Worth knowing

Sandalwood and lavandin oils carry four declared fragrance allergens including coumarin; patch test if fragrance-reactive.

How to use

Evenings only. Two to three pumps on clean, dry skin, two to three nights a week, building to nightly as tolerated.

Follow with moisturiser. SPF every morning.

Layering

Use alongside

A gentle cleanse and plain moisturiser, the standard retinoid evening. Morning antioxidants complement from the other end of the day.

Keep apart from

Define, Refine, exfoliating acids and enzyme masks on the same night, one vitamin A source, one night.

Before you start

Not suitable if

You are pregnant
Pregnancy and breastfeeding
Concurrent use of other retinoids or exfoliants without advice
Recent professional peel or resurfacing
Known sandalwood, lavender or fragrance allergy

Good to know

Patch test on a small area of skin before first full use
Increases skin sensitivity to UV. Use broad-spectrum SPF 30 or higher daily

Full ingredients

Aqua/Water/Eau, Hamamelis Virginiana (Witch Hazel) Water, Carthamus Tinctorius (Safflower) Oleosomes, Glycerin, Phospholipids, Sodium Acrylates Copolymer, Hydrogenated Polyisobutene, Sodium Lactate, Polysorbate 20, Cetyl Alcohol, Retinal, Retinol, Proline (L), Sodium Hyaluronate (L), Helianthus Annuus (Sunflower) Seed Oil, Tapioca Starch, Leuconostoc/Radish Root Ferment Filtrate, Lonicera Caprifolium (Honeysuckle) Flower Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Santalum Austrocaledonicum (Sandalwood) Wood Oil, Lavandula Hybrida (Lavandin) Oil, Galactoarabinan, Glycosaminoglycans, Sodium Polygamma-Glutamate, Tocopherol (D-Alpha), Squalane, Hydroxypropyl Starch Phosphate, Dimethicone, Polyglyceryl-10 Stearate, Gluconic Acid, Xanthan Gum, Tetrasodium EDTA, Citric Acid, Alcohol, Potassium Sorbate, Sodium Glycolate, Sodium Hydroxide, Trisodium EDTA, Benzoic Acid, Sodium Benzoate, Linalool, Limonene, Coumarin, Geraniol

Verified against Australian stock on 21 August 2026.

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