Define

Name: Define
Brand: Cosmedix
SKU: CMX-DEF-45
Price: 142.00 AUD
Availability: InStock

$142.00

A night-use resurfacing treatment combining retinol with exfoliating acids, for experienced users under practitioner guidance.

Key actives Lactic Acid·Retinol·Retinyl Palmitate·Resveratrol (Ferment)·Witch Hazel·Bisabolol

When to use Evening, 2 nights a week building as tolerated

How it works

An AHA trio with a vitamin A engine

L-lactic acid leads, joined by tartaric and malic, three alpha-hydroxy acids of different sizes working the surface, while retinyl acetate, retinol and retinyl palmitate convert toward retinoic acid at three speeds beneath it. Surface and cellular resurfacing in the same cream is what puts this in the advisory tier.

The antioxidant thread

Fermented resveratrol and its stabilised ether, with vitamin E in two forms and carrot extract, defence running alongside the resurfacing.

The buffering

Witch hazel water, bisabolol, allantoin, aloe and marshmallow root are woven through to keep a working formula wearable.

Non-negotiable

Evenings only; retinisation-plus-acid adjustment is real. Daily broad-spectrum SPF every morning, without exception.

Who it suits

Experienced actives users working on texture, tone and fine lines together, skin already comfortable with nightly retinol or regular acids.

Not the place to start

New to either pathway? Build tolerance with a single-pathway product first.

Not suitable

During pregnancy or while breastfeeding, in line with standard retinoid guidance.

How to use

Evenings only. Start with a pea-sized amount two nights a week on clean, dry skin, building slowly as tolerated.

Follow with moisturiser. SPF every morning is part of using this product.

Layering

Use alongside

A gentle cleanse (Benefit Clean) and a plain moisturiser. That is the whole evening on Define nights.

Keep apart from

All other retinoids, exfoliating acids, Pure Enzymes and Purity Clean on the same day, this cream is already both pathways.

Before you start

Not suitable if

You are pregnant
Pregnancy and breastfeeding
Egg allergy (contains albumen)
Tree nut allergy (contains sweet almond oil)
Asteraceae (daisy family) allergy — contains chamomile
Concurrent use of other retinoids or exfoliants
Recent professional peel or resurfacing
Known citrus or fragrance allergy

Good to know

Patch test on a small area of skin before first full use
Increases skin sensitivity to UV. Use broad-spectrum SPF 30 or higher daily

Full ingredients

Aqua/Water/Eau, Polysorbate 60, Lactic Acid (L), Isopropyl Myristate, Glyceryl Stearate, Hamamelis Virginiana (Witch Hazel) Water, Stearic Acid, Cetearyl Alcohol, Glycerin, Sodium Hydroxide, Leuconostoc/Radish Root Ferment Filtrate, Tartaric Acid (L), Retinyl Acetate, Albumen, Cetyl Alcohol, Benzyl Alcohol, Malic Acid (L), Olea Europaea (Olive) Fruit Oil, Retinol, Pichia/Resveratrol Ferment Extract, Resveratrol Dimethyl Ether, Galactoarabinan, Proline (L), Retinyl Palmitate, Citrus Grandis (Grapefruit) Peel Oil, Cananga Odorata (Ylang Ylang) Flower Oil, Bisabolol (L-Alpha), Tocopheryl Acetate (D-Alpha), Aloe Barbadensis Leaf Juice Powder, Allantoin, Daucus Carota Sativa (Carrot) Root Extract, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Helianthus Annuus (Sunflower) Seed Oil, Chamomilla Recutita (Matricaria) Flower Extract, Tocopherol (D-Alpha), Althaea Officinalis (Marshmallow) Root Extract, Alcohol, Citric Acid, Polysorbate 20, Potassium Sorbate, Limonene, Sodium Gluconate, BHA, Behenyl Alcohol, Caprylhydroxamic Acid, Alcohol Denat., BHT, Xanthan Gum, Phenoxyethanol

Verified against Australian stock on 21 August 2026.

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